The aim of the iP-Osteo project is to develop hybrid materials for regeneration of the large osteochondral defects in elderly people. The aim will be achieved by developing the active scaffolds that can attract the cells to the defect site needed the regeneration. To enable the regeneration of both bone and cartilage, bilayer scaffolds will be made. The first scaffold layer will be made my electrospinning of biodegradable polymers and active molecules promoting the bone regeneration. The scaffolds will be optimized to have the needed composition, pore size and mechanical properties. The scaffolds will then be combined with hydrogels optimized for cartilage regeneration. To enable effective healing of the tissue in patients with reducing regeneration capacity (elderly patients), active molecules will be encapsulated in both fibers and particles. The time-regulated release of the active molecules will lead to faster and more complete healing.